The phototoxicity of phenothiazinium-based photosensitizers to bacterial membranes
نویسندگان
چکیده
منابع مشابه
Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps.
Antimicrobial photodynamic therapy (PDT) combines a nontoxic photoactivatable dye, or photosensitizer (PS), with harmless visible light to generate singlet oxygen and free radicals that kill microbial cells. Although the light can be focused on the diseased area, the best selectivity is achieved by choosing a PS that binds and penetrates microbial cells. Cationic phenothiazinium dyes, such as m...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2006
ISSN: 0928-8244,1574-695X
DOI: 10.1111/j.1574-695x.2005.00017.x